Gene panels

Multiplexed gene panels

Using Luminex xTAG® technology, we carry out differential gene expression studies through mRNA quantification in a simple way without the need for prior amplification steps or library preparation, which avoids processing biases.

 

Purified RNA, whole blood, fresh or frozen tissue samples, paraffin-embedded samples and cell cultures, among others, can be used as starting material.

 

This type of analysis is particularly suitable for degraded samples, which is a great advantage over other techniques that require excellent quality starting material.

Custom multi-disease panels

We provide our customers with a catalogue of more than 17,000 genes to design customised gene panels according to their own needs.

 

An example is showed below with three pre-configured panels including 80 genes each:

PYCARD, MAPK3, SUGT1, MAP3K7IP1, MAP3K7, MEFV, MAPK12, PSTPIP1, MAPK13, TNFSF14, PEA15, RIPK2, PANX1, NLRX1, NALP1, NLRP9, TNFSF4, P2RX7, NLRP4, MAP3K7IP2, BIRC1, NLRC5, BIRC4, NLRP3, NLRP5, AIM2, BIRC2, CARD6, CASP1, CASP5, CHUK, CIITA, CTSB, HSP90AA1, TRA1, IKBKB, IKBKG, IRF2, MAPK9, NFKB1, MAPK8, NFKBIA, RAGE, TNF, TNFSF5, IL12A, BCL2, TNFSF11, ICEBERG, CASP4, IRF1, IL12B, MAPK1, GAPDH, CXCL1, CASP8, TRAF6, CXCL2, CCL5, CCL7, RELA, PTGS2, IFNG, IL6, TIRAP, IRAK1, ACTB, IL1B, TXNIP, MYD88, CARD12, BIRC3, CCL2, PPIB, IFNB1, NOD2, IL18, BCL2L1, HSPCB y NALP12.

NUSAP1, ERBB3, WNT2, SPARC, RAB17, PRAME, GJB1, SLC7A1, MCAM, RNF157, ACSL3, TRPM4, CACNA1D, TOP2A, BRAF, SPARCL1, MYLK, BIRC5, ARPC2, CDKN1B, POU2F3, CCNE1, FN1, E2F1, ZNF577, PHIP, HIF1A, KIF20A, MAGEA1, C10orf137, HPRT1, BUB1, CASP8, KLK3, CDKN2B, CCND1, RB1, CDH2, YWHAZ, MCM6, DSC1, MCM4, MITF, VCAN, SPP1, MKI67, MYRIP, PCSK6, TP53, NCOA3, PCNA, TFRC, F10, ITGB1, CCR7, PGK1, PTEN, ITGB3, MMP10, MMP9, GSTP1, MMP2, MLANA, BCL2A1, RAD54B, MET, GCNT1, AQP3, MCM10, WNT5A, DCT, TBP, GPC3, CDKN2A, PRKCA, ITGB4, CRISP3, CCNA1, GUSB y PLAUR.

CASP6, CARD8, BNIP2, DAPK1, BAG3, HPRT1, TNFRSF10A, BID, TNFRSF7, LTBR, TNFRSF9, BIRC8, CASP3, TP53, BIRC3, TNFRSF1A, PYCARD, AKT1, BRAF, TP53BP2, BAD, BCL2L1, TP73, GADD45A, FADD, TNFRSF21, BCL2L2, NOL3, FASLG, CASP8, PPIB, CASP4, CASP1, CASP2, BCLAF1, ABL1, TNF, TNFSF10, TNFRSF11B, APAF1, TNFSF8, CASP14, IGF1R, BCL10, LTA, TNFRSF10B, CASP9, BCL2L11, TRAF4, BFAR, MCL1, BIRC6, TNFSF5, BAG1, BCL2A1, BAK1, CIDEB, TRAF2, TRAF3, CFLAR, CASP10, CD40, BNIP3L, RIPK2, CASP7, BAG4, BIRC1, BCL2L10, TRADD, BNIP1, TNFRSF25, BAX, BNIP3, BIRC2, CARD4, CARD6, CIDEA, FAS, BCL2 y BIK.

Custom multi-disease panels

We provide our customers with a catalogue of more than 17,000 genes to design customised gene panels according to their own needs.

 

An example is showed below with three pre-configured panels including 80 genes each:

PYCARD, MAPK3, SUGT1, MAP3K7IP1, MAP3K7, MEFV, MAPK12, PSTPIP1, MAPK13, TNFSF14, PEA15, RIPK2, PANX1, NLRX1, NALP1, NLRP9, TNFSF4, P2RX7, NLRP4, MAP3K7IP2, BIRC1, NLRC5, BIRC4, NLRP3, NLRP5, AIM2, BIRC2, CARD6, CASP1, CASP5, CHUK, CIITA, CTSB, HSP90AA1, TRA1, IKBKB, IKBKG, IRF2, MAPK9, NFKB1, MAPK8, NFKBIA, RAGE, TNF, TNFSF5, IL12A, BCL2, TNFSF11, ICEBERG, CASP4, IRF1, IL12B, MAPK1, GAPDH, CXCL1, CASP8, TRAF6, CXCL2, CCL5, CCL7, RELA, PTGS2, IFNG, IL6, TIRAP, IRAK1, ACTB, IL1B, TXNIP, MYD88, CARD12, BIRC3, CCL2, PPIB, IFNB1, NOD2, IL18, BCL2L1, HSPCB y NALP12.

NUSAP1, ERBB3, WNT2, SPARC, RAB17, PRAME, GJB1, SLC7A1, MCAM, RNF157, ACSL3, TRPM4, CACNA1D, TOP2A, BRAF, SPARCL1, MYLK, BIRC5, ARPC2, CDKN1B, POU2F3, CCNE1, FN1, E2F1, ZNF577, PHIP, HIF1A, KIF20A, MAGEA1, C10orf137, HPRT1, BUB1, CASP8, KLK3, CDKN2B, CCND1, RB1, CDH2, YWHAZ, MCM6, DSC1, MCM4, MITF, VCAN, SPP1, MKI67, MYRIP, PCSK6, TP53, NCOA3, PCNA, TFRC, F10, ITGB1, CCR7, PGK1, PTEN, ITGB3, MMP10, MMP9, GSTP1, MMP2, MLANA, BCL2A1, RAD54B, MET, GCNT1, AQP3, MCM10, WNT5A, DCT, TBP, GPC3, CDKN2A, PRKCA, ITGB4, CRISP3, CCNA1, GUSB y PLAUR.

CASP6, CARD8, BNIP2, DAPK1, BAG3, HPRT1, TNFRSF10A, BID, TNFRSF7, LTBR, TNFRSF9, BIRC8, CASP3, TP53, BIRC3, TNFRSF1A, PYCARD, AKT1, BRAF, TP53BP2, BAD, BCL2L1, TP73, GADD45A, FADD, TNFRSF21, BCL2L2, NOL3, FASLG, CASP8, PPIB, CASP4, CASP1, CASP2, BCLAF1, ABL1, TNF, TNFSF10, TNFRSF11B, APAF1, TNFSF8, CASP14, IGF1R, BCL10, LTA, TNFRSF10B, CASP9, BCL2L11, TRAF4, BFAR, MCL1, BIRC6, TNFSF5, BAG1, BCL2A1, BAK1, CIDEB, TRAF2, TRAF3, CFLAR, CASP10, CD40, BNIP3L, RIPK2, CASP7, BAG4, BIRC1, BCL2L10, TRADD, BNIP1, TNFRSF25, BAX, BNIP3, BIRC2, CARD4, CARD6, CIDEA, FAS, BCL2 y BIK.

A wide variety of applications available

The study of differential gene expression by direct mRNA quantification has a wide variety of applications:

 

  • Verification of biomarkers.
  • Validation of genes found by CHIP or NGS.
  • Subclassification of tumours.
  • Retrospective analysis of paraffin-embedded or coverslip-stained samples.
  • Analysis of xenografts.
  • Detection of translocations and fusion genes.
  • Toxicological tests.

Wide range of applications

The study of differential gene expression by direct mRNA quantification has a wide variety of applications:

  • Verification of biomarkers.
  • Validation of genes found by CHIP or NGS.
  • Subclassification of tumours.
  • Retrospective analysis of samples in paraffin or stained on coverslips.
  • Analysis of xenografts.
  • Detection of translocations and fusion genes.
  • Toxicological tests.

Wide range of applications

The study of differential gene expression by direct mRNA quantification has a wide variety of applications:

  • Verification of biomarkers.
  • Validation of genes found by CHIP or NGS.
  • Subclassification of tumours.
  • Retrospective analysis of samples in paraffin or stained on coverslips.
  • Analysis of xenografts.
  • Detection of translocations and fusion genes.
  • Toxicological tests.

Differential expression studies at gene and protein level

We study the differential expression of more than 600 proteins organised in panels, both pre-configured and customer-configurable, using Luminex xMAP® technology.

 

Thanks to this technology, we can globally study a single sample to obtain the maximum possible information and identify proteins or mRNAs that serve as effective indicators of biological processes, pathological processes or possible responses to treatment.

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