In DREAMgenics we design and develop panels of genes and / or genomic regions of interest to support molecular diagnosis, adapted to clinicians and researchers’ needs.
To guarantee the usefulness of diagnostic panels, it is necessary to know the needs of each client. Our team of experts offers a completely personalized advice, including scientific and technical solutions, to obtain quality results with the lowest economic investment.
We will carry out an exhaustive research, based on literature and databases to identify genes and / or genomics regions with scientific evidence in favor of their association with pathologies of interest.
Our collaboration with the most reliable sequencing providers allows us to select the most suitable platform for your project. The panel will be subjected to technical and clinical (if necessary) validations.
DREAMgenics bioinformatics framework has been designed to easily adapt to client needs, intengrating algorithms, pipelines, databases, etc. The bioinformatic analysis includes:
- – Detection of high quality variants (SVs, SNVs, CNVs)
- – Filtering of population common variants.
- – Annotation of the variants using multiple databases and prediction algorithms.
- – Comparison between samples and extraction of recurrent variants.
Our analyses identify high quality genomic variants through excellent sensitivity and specificity standards, extracting meaningful biological information and reducing validation process costs. The results will be delivered through a detailed report. In addtition, we offer the possibility of advanced visualization and interactive review of results through our exclusive DG Reports web application.
What is a genetic disease?
A genetic disease is any disease caused by alterations in the genetic material. Genes are made up of DNA sequences that encode proteins, and these proteins are responsible for nearly every function within the cell. If there are alterations in the genes, the proteins may not work correctly and lead to diseases.
Are all genetic diseases hereditary?
Some genetic diseases are inherited conditions than can be passed on through generations. However, sometimes the alterations in the DNA occur spontaneously, without previous familial cases. Therefore, all hereditary diseases are genetic, but not all genetic diseases are hereditary.
What is genetic predisposition?
The genetic susceptibility or predisposition is the increased likelihood of suffering a condition of genetic origin due to the presence of mutations in genes related to the disease. In families with several members affected by a condition, the doctor will assess if there is a genetic predisposition to it. It is important to point out that the predisposition indicates a increases the chance of suffering a disease, but it does not necessarily mean that you will definitely get that disease. Besides, the probability of developing it may increase with an inappropriate lifestyle.
What is a genetic analysis?
A genetic analysis is a test carried out by accredited laboratories that analyzes the DNA in order to identify the genetic causes (mutations) of a certain disease. They can have a preventive value since they allow to diagnose and to prevent the disease at its initial stages. In DREAMgenics we analyze and interpret alterations in the DNA in order to know their clinical effects.
What are the benefits of genetics testing in relation to treatment?
Once the cause of a genetic disease is found, it is possible to treat each patient with specific therapies avoiding adverse side effects and ineffective treatments. In addition, the dosage and duration of a treatment may be established in a personalized way. In certain cases, the information obtained with the test can facilitate participation in clinical trials, specifically designed according to the genetic alterations of patients.