Logo-Dreamgenics
Logo-Dreamgenics

Otorhinolaryngology

Approximately 80% of prelingual deafness has a genetic origin and, to date, more than 6,000 alterations have been identified that cause Non-Syndromic Hearing Loss and more than 400 syndromes that cause hearing loss.
Clinical areas
DG Otorhinolaryngology
Non-syndromic hearing loss
Mitochondrial hearing loss
Syndromic hearing loss
Documentation
Application form

DG Otolaryngology I 329 genes

ABCC1, ABHD12, ACSL4, ACTB, ACTG1, ADCY1, ADGRV1, AFG2A, AFG2B, AIFM1, AK2, ALMS1, AMMECR1, ANKH, AP1B1, AP1S1, AP3D1, ARSG, ATOH1, ATP11A, ATP1A3, ATP2B2, ATP6V0A4, ATP6V1B1, ATP6V1B2, BCAP31, BCS1L, BDP1, BSND, BTD, CABP2, CACNA1D, CCDC50, CD151, CD164, CDC14A, CDH11, CDH23, CDK5RAP2, CEACAM16, CENPP, CEP250, CEP78, CHD7, CIB2, CISD2, CLCNKA, CLCNKB, CLDN14, CLDN9, CLIC5, CLPP, CLRN1, CLRN2, COCH, COL11A1, COL11A2, COL2A1, COL4A3, COL4A4, COL4A5, COL4A6, COL9A1, COL9A2, COL9A3, COLEC11, COQ6, CRLS1, CRYM, DAP3, DCAF17, DCDC2, DDX11, DHX16, DIABLO, DIAPH1, DIAPH3, DLX5, DMP1, DMXL2, DNAJC3, DNMT1, DSPP, ECHS1, EDN3, EDNRB, ELMOD3, EPHA10, EPS8, EPS8L2, ERAL1, ERCC3, ESPN, ESRP1, ESRRB, EXOSC2, EYA1, EYA4, FDXR, FGF3, FGFR1, FGFR2, FGFR3, FITM2, FKBP14, FOXC1, FOXI1, GAB1, GAS2, GATA2, GATA3, GDF6, GFER, GGPS1, GIPC3, GJB1, GJB2, GJB3, GJB6, GLA, GLIS3, GPC4, GPR156, GPRASP2, GPSM2, GRAP, GREB1L, GRHL2, GRXCR1, GRXCR2, GSDME, HARS1, HARS2, HGF, HOMER2, HOXA1, HOXA2, HSD17B4, HUWE1, IARS2, IGF1, IKZF2, ILDR1, JAG1, KARS1, KCNE1, KCNE5, KCNJ10, KCNJ16, KCNQ1, KCNQ4, KIT, KITLG, KLC4, KMT2D, LARS2, LHFPL5, LHX3, LMX1A, LOXHD1, LRP2, LRTOMT, MAF, MAFB, MAN2B1, MAP1B, MAP3K7, MARS2, MARVELD2, MASP1, MCM2, MET, MIA3, MINAR2, MITF, MPZ, MPZL2, MRPL49, MRPS2, MRPS7, MSRB3, MYH14, MYH9, MYO15A, MYO3A, MYO6, MYO7A, NARS2, NDP, NDUFA13, NF2, NLRP3, NMNAT1, OPA1, OSBPL2, OTOA, OTOF, OTOG, OTOGL, P2RX2, PAX1, PAX2, PAX3, PBX1, PCDH15, PDE1C, PDSS1, PDZD7, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PHYH, PI4KB, PJVK, PKHD1L1, PLOD3, PLS1, PMP22, PNPT1, POGZ, POLD1, POU3F4, POU4F3, PPIP5K2, PRORP, PRPS1, PSMC1, PSMC3, PTPN11, PTPRQ, RAI1, RDX, REST, RFC4, RFT1, RIPOR2, RMND1, RNF220, ROR1, RPGR, RRM2B, S1PR2, SALL1, SALL4, SARS1, SCD5, SDHD, SERAC1, SERPINB6, SGPL1, SIX1, SIX5, SLC12A2, SLC17A8, SLC19A2, SLC26A4, SLC26A5, SLC29A3, SLC33A1, SLC44A4, SLC4A11, SLC52A2, SLC52A3, SLC9A1, SLITRK6, SMAD4, SMPX, SNAI2, SOX10, SOX2, SPNS2, SPTBN4, SRP72, STRC, STX4, SUCLA2, SYNE4, TBC1D24, TCOF1, TECTA, THOC1, THRB, TIMM8A, TMC1, TMEM132E, TMEM43, TMIE, TMPRSS3, TMTC4, TNC, TPRN, TRIOBP, TRPV4, TRRAP, TSPEAR, TTR, TUBB4B, TWIST1, TWNK, TXNL4A, TYR, UBR1, UNC45A, USH1C, USH1G, USH2A, USP48, USP53, VDR, VPS13B, VPS33B, WBP2, WFS1, WHRN, XYLT2, YAP1, YARS1, ZSCAN10.
Targeted exome sequencing that includes the analysis of more than 320 genes associated or potentially associated with the development of syndromic and non-syndromic hearing loss, enabling the identification of the molecular cause of patients’ hearing impairment.
Targeted Exoma
Information
  • Analysis: SNVs, Indels and CNVs
  • Medium coverage: >100X
  • Delivery time: 30 working days

Non-syndromic hearing loss I 4 studies

Hearing loss exhibits significant genetic heterogeneity, with more than 6,000 genetic variants known to date that cause non-syndromic hearing loss. We offer targeted exome sequencing for this type of hearing loss.
ABCC1, ACTG1, ADCY1, AFG2B, AIFM1, ATOH1, ATP11A, ATP2B2, BDP1, BSND, CABP2, CCDC50, CD164, CDC14A, CDH23, CEACAM16, CENPP, CIB2, CLDN14, CLDN9, CLIC5, CLRN2, COCH, COL11A1, COL11A2, COL4A6, CRYM, DCDC2, DIABLO, DIAPH1, DIAPH3, DMXL2, DSPP, ELMOD3, EPHA10, EPS8, EPS8L2, ESPN, ESRP1, ESRRB, EYA4, FOXI1, GAB1, GAS2, GIPC3, GJB2, GJB3, GJB6, GPR156, GPRASP2, GRAP, GREB1L, GRHL2, GRXCR1, GRXCR2, GSDME, HGF, HOMER2, ILDR1, KARS1, KCNJ10, KCNQ4, KITLG, LHFPL5, LMX1A, LOXHD1, LRTOMT, MAP1B, MARVELD2, MCM2, MET, MINAR2, MPZL2, MSRB3, MYH14, MYH9, MYO15A, MYO3A, MYO6, MYO7A, NARS2, NLRP3, OSBPL2, OTOA, OTOF, OTOG, OTOGL, P2RX2, PCDH15, PDE1C, PDZD7, PI4KB, PJVK, PKHD1L1, PLS1, PNPT1, POU3F4, POU4F3, PPIP5K2, PRPS1, PTPRQ, RDX, REST, RIPOR2, ROR1, S1PR2, SCD5, SERPINB6, SIX1, SLC12A2, SLC17A8, SLC26A4, SLC26A5, SLC44A4, SLITRK6, SMPX, SPNS2, STRC, STX4, SYNE4, TBC1D24, TECTA, THOC1, TMC1, TMEM132E, TMIE, TMPRSS3, TMTC4, TNC, TPRN, TRIOBP, TRRAP, TSPEAR, USH1C, USP48, WBP2, WFS1, WHRN.
ABCC1, ACTG1, ATOH1, ATP11A, ATP2B2, CCDC50, CD164, CEACAM16, CENPP, COCH, COL11A1, COL11A2, CRYM, DIABLO, DIAPH1, DIAPH3, DMXL2, DSPP, ELMOD3, EPHA10, ESPN, EYA4, GJB2, GJB3, GJB6, GREB1L, GRHL2, GSDME, HOMER2, KCNQ4, KITLG, LMX1A, MAP1B, MCM2, MYH14, MYH9, MYO3A, MYO6, MYO7A, NLRP3, OSBPL2, P2RX2, PDE1C, PI4KB, PLS1, POU4F3, PTPRQ, REST, RIPOR2, SCD5, SIX1, SLC12A2, SLC17A8, SLC44A4, TBC1D24, TECTA, THOC1, TMC1, TNC, TRRAP, USP48, WFS1.
ADCY1, AFG2B, ATP2B2, BDP1, BSND, CABP2, CDC14A, CDH23, CEACAM16, CIB2, CLDN14, CLDN9, CLIC5, CLRN2, COCH, COL11A2, DCDC2, ELMOD3, EPS8, EPS8L2, ESPN, ESRP1, ESRRB, FOXI1, GAB1, GAS2, GIPC3, GJB2, GJB3, GJB6, GPR156, GRAP, GRXCR1, GRXCR2, HGF, ILDR1, KARS1, KCNJ10, LHFPL5, LOXHD1, LRTOMT, MARVELD2, MET, MINAR2, MPZL2, MSRB3, MYO15A, MYO3A, MYO6, MYO7A, NARS2, OTOA, OTOF, OTOG, OTOGL, PCDH15, PDZD7, PJVK, PKHD1L1, PNPT1, PPIP5K2, PTPRQ, RDX, RIPOR2, ROR1, S1PR2, SERPINB6, SLC26A4, SLC26A5, SLITRK6, SPNS2, STRC, STX4, SYNE4, TBC1D24, TECTA, TMC1, TMEM132E, TMIE, TMPRSS3, TMTC4, TPRN, TRIOBP, TSPEAR, USH1C, WBP2, WHRN.
AIFM1, COL4A6, GPRASP2, POU3F4, PRPS1, SMPX.
Targeted Exoma
Information
  • Analysis: SNVs, Indels and CNVs
  • Medium coverage: >100X
  • Delivery time: 30 working days

Mitochondrial hearing loss I: 1 study

We offer a targeted test to detect mitochondrial DNA variants associated with hereditary hearing loss, enabling an accurate diagnosis of these conditions. This analysis allows for the identification of variants such as those described in the MT-RNR1 gene, which are linked to sensorineural hearing loss and aminoglycoside sensitivity, among others.

MTCO1, MTND1, MTRNR1, MTTH, MTTI, MTTK, MTTL1, MTTS1, MTTS2.
Targeted Exoma
Information
  • Analysis: SNVs, Indels and CNVs
  • Medium coverage: >100X
  • Delivery time: 30 working days

Syndromic hearing loss I: 1 study

More than 400 syndromes associated with hearing loss are known, making their genetic study complex. We offer an exome test specifically designed to study the most common syndromes associated with sensorineural hearing loss, such as Waardenburg syndrome, branchio-oto-renal syndrome, Usher syndrome, Pendred syndrome, and Jervell and Lange-Nielsen syndrome, among others.
ABHD12, ACSL4, ACTB, ACTG1, ADGRV1, AFG2A, AFG2B, AIFM1, AK2, ALMS1, AMMECR1, ANKH, AP1B1, AP1S1, AP3D1, ARSG, ATP1A3, ATP6V0A4, ATP6V1B1, ATP6V1B2, BCAP31, BCS1L, BSND, BTD, CACNA1D, CD151, CDH11, CDH23, CDK5RAP2, CEP250, CEP78, CHD7, CIB2, CISD2, CLCNKA, CLCNKB, CLPP, CLRN1, COL11A1, COL11A2, COL2A1, COL4A3, COL4A4, COL4A5, COL9A1, COL9A2, COL9A3, COLEC11, COQ6, CRLS1, DAP3, DCAF17, DDX11, DIAPH1, DIAPH3, DLX5, DMP1, DNAJC3, DNMT1, DSPP, ECHS1, EDN3, EDNRB, ERAL1, ERCC3, ESPN, EXOSC2, EYA1, FDXR, FGF3, FGFR1, FGFR2, FGFR3, FITM2, FKBP14, FOXC1, FOXI1, GATA2, GATA3, GDF6, GFER, GGPS1, GJB1, GJB2, GJB3, GJB6, GLA, GLIS3, GPC4, GPSM2, HARS1, HARS2, HOXA1, HOXA2, HSD17B4, HUWE1, IARS2, IGF1, IKZF2, JAG1, KARS1, KCNE1, KCNE5, KCNJ10, KCNJ16, KCNQ1, KIT, KITLG, KLC4, KMT2D, LARS2, LHX3, LRP2, MAF, MAFB, MAN2B1, MAP3K7, MARS2, MASP1, MIA3, MITF, MPZ, MRPL49, MRPS2, MRPS7, MYH14, MYH9, MYO7A, NDP, NDUFA13, NF2, NLRP3, NMNAT1, OPA1, OTOF, PAX1, PAX2, PAX3, PBX1, PCDH15, PDSS1, PDZD7, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PHYH, PLOD3, PMP22, PNPT1, POGZ, POLD1, PRORP, PRPS1, PSMC1, PSMC3, PTPN11, RAI1, RFC4, RFT1, RMND1, RNF220, RPGR, RRM2B, SALL1, SALL4, SARS1, SDHD, SERAC1, SGPL1, SIX1, SIX5, SLC12A2, SLC19A2, SLC26A4, SLC29A3, SLC33A1, SLC4A11, SLC52A2, SLC52A3, SLC9A1, SMAD4, SNAI2, SOX10, SOX2, SPTBN4, SRP72, SUCLA2, TBC1D24, TCOF1, THRB, TIMM8A, TMEM43, TRPV4, TTR, TUBB4B, TWIST1, TWNK, TXNL4A, TYR, UBR1, UNC45A, USH1C, USH1G, USH2A, USP53, VDR, VPS13B, VPS33B, WFS1, WHRN, XYLT2, YAP1, YARS1, ZSCAN10.
Targeted Exoma
Information
  • Analysis: SNVs, Indels and CNVs
  • Medium coverage: >100X
  • Delivery time: 30 working days